DNA Amplification

Polymerase chain reaction (PCR) is a technique widely used in molecular diagnostics. DNA is used as a template for replication. PCRs make it is possible to amplify a single copy of DNA and generate several million copies. The main PCR method uses a thermal cycling technique, which rapidly heats and cools the DNA sample to a defined series of temperature steps. PCR requires a high number of thermal cycle steps to create thousands of strands of DNA sequencing for analysis. This is a harsh environment for standard thermoelectric modules due to the mechanical stresses that occur during the heating and cooling stage.

The Laird Thermal Systems PC Series (Power Cycling) of TEMs are designed for high reliability applications such as PCR thermal cycling, which require extended mean time between failure (MTBF). Tested to more than 1 million temperature cycles, the PC Series enhances the reliability of PCR cyclers and offers a significantly longer operating life and lower overall cost of ownership compared to standard TEMs.

Additional advantages of thermoelectric modules compared to other types of thermal cycling devices are precise temperature control, compactness, faster temperature ramp rates and efficiency.

Laird Thermal Systems’ PC Series TEMs enhances reliability and extends the operating life of PCR machines.
Read application note: Thermoelectric Modules Accelerate PCR Thermal Cycling
Read press release: Laird’s Power Cycling Thermoelectric Modules Enhance Reliability of PCR Cyclers